Then, it is possible that CD36 can act synergistically with TLR in CD14++CD16+ intermediate and CD14+CD16++ non-classical monocytes, probably induced by oxLDL, inducing the production of inflammatory cytokines, increasing the low-grade inflammation and the appearance of comorbidities observed during the obesity. This evidence concerns the gene CD14 and obesity due to melanocortin 4 receptor deficiency.