TNF and obesity due to melanocortin 4 receptor deficiency: In addition, we demonstrated a decreased in IL-10 expression in childhood obesity, which would be an event that supports expression of inflammatory cytokines, since IL-10 regulates expression of IL-1β, IL-6, IL-8, IL-12 and TNF-α [29, 30] Moreover, this lower expression of IL-10 may be decisive for inducing and/or maintaining the low-grade inflammation status observed in children with obesity.