Because of failure in eyelid closure, the eyes of mice harboring EOB phenotype are open at birth unlike wildtype mice whose eyes are closed at birth but open by 12 to 14 days postpartum.[13,15] We also found that deletion of LGR4 in mice can cause anterior segment dysgenesis and onset of age-related cataracts.[12,14] There is, however, no report about the role of LGR4 in the regulation of RPE functional activity. This evidence concerns the gene LGR4 and Age-related cataract.