In the present study, we explored the expression patterns of Derlin-1 in bladder cancer tissues and further investigated the correlation between bladder cancer and Derlin-1 protein expression as well as the correlation between Derlin-1 expression and clinicopathologic characteristics and prognosis, to better understand its role in tumor biology and its potential implications for cancer progression. This evidence concerns the gene DERL1 and urinary bladder carcinoma.