In our study, positive Derlin-1 expression was associated with poor 5-year OS in bladder cancer, which is consistent with the evidence provided by Dong et al. [15], In addition, Derlin-1 was highly expressed in BC cell line T24, and interfere of Derlin-1 led to the decrease in cell migration and invasion in T24 cells, indicating that Derlin-1 may play an essential role in tumor progression and metastasis. The gene discussed is DERL1; the disease is urinary bladder cancer.