It is noticeable that E7 nonsynonymous mutations (S52D, 55D, H61Y, D64N and L99R) were harbored by lineage C, but not by lineage B. E7 interacts with the retinoblastoma (Rb) protein, causing uncontrolled cell division and inactivating its function as a tumor suppressor [30, 31]. The gene discussed is RB1; the disease is neoplasm.