As such, some data show that higher TRAP1 expression reduces cell motility,16, 37 but also increases metastasis in prostate 26 and colorectal 16 cancers, and confers resistance to conditions normally impairing cell migration.15, 16 Accordingly, in this study we show that an inverse correlation between TRAP1 and p70S6K previously found in colorectal cancer is conserved in OC cells and patients, and that this correlation affects cell migration, resulting in increased motility of cells with low TRAP1/high p70S6K levels. The gene discussed is RPS6KB1; the disease is colorectal cancer.