Since there is doubt as to whether plasminogen deficiency is a risk factor of thrombotic disease by itself or in combination with other abnormalities1, we genotyped 12 genetic risk factors of thrombosis coded by F2, F5, F12, F13A1, ABO, SERPINA10 and SERPINC1 loci to evaluate the putative role of plasminogen deficiency phenotype in thrombotic disease. This evidence concerns the gene SERPINC1 and deep vein thrombosis.