Some studies reported significantly higher percentage of CD4+CD25+FoxP3+ Treg in patients with advanced/metastatic NSCLC compared to healthy donors29, 30, 31, 32, whereas the high percentage of CD152+CD4+CD25high FoxP3+ Tregs correlates with more advanced stage of disease29, 33. The gene discussed is FOXP3; the disease is non-small cell lung carcinoma.