MSN and inflammatory response: Moesin and Ezrin, but not Radixin, are directly involved in LPS-induced EC barrier disruption in vitro. Further, introduction of phospho-null Moesin mutant into the mouse lung significantly attenuates LPS-induced lung inflammation and vascular leak suggesting that Moesin dephosphorylation may protect against lung injury in a LPS-mediated murine model of ALI in vivo.