SNCA and Parkinson disease: In this regard, it is also interesting that over-expression of Rab1 could rescue the SNCA mutant phenotype in invertebrate and mammalian models and in human neurons carrying PD-associated SNCA triplication [37, 38], indicating that several PARK genes with quite distinct clinical manifestations (early onset, typical PD, or dementia with Lewy body) may share common molecular mechanisms [39].