In previous studies researchers reported significantly higher global expression of MMP-1, MMP-7, and MMP-14, TIMP-1 and TIMP-3 in the core of breast cancer tumors, in comparison with lymphatic axillary ganglia, but expression of the same markers in ganglia did not appear associated with prognosis of development not in near, neither in distant metastasis [19]. The gene discussed is TIMP1; the disease is breast carcinoma.