Adoptive Cell Therapy in colorectal cancer includes: tumor-infiltrating lymphocytes (TILs) in metastatic digestive tract cancers; T cells engineered to target VEGFR in patients with metastatic cancer; T cells engineered to target MAGE-A3 in patients with metastatic cancer that expresses MAGE-A3; T cells targeting EGFR in patients with advanced cancer, including colorectal cancer; natural killer (NK) cells, important innate immune cells, in patients with advanced cancer [25]. This evidence concerns the gene EGFR and metastatic malignant neoplasm.