The trauma-induced inflammatory response in the BD ≥ 4 group was characterized by both innate immune (IL-1β, GM-CSF, MIP-1α/CCL3, MIP-1β/CCL4, sIL-1Rα, IFN-α, and IFN-γ) and lymphoid (IL-17A, IL-7, IL-4, IL-2, IL-13, and IL-15) pathways. The gene discussed is IL1B; the disease is Behcet disease.