The treatment with the inducer of HO-1 (hemin) had beneficial effects in PbA infected DBA/2 mice and in PMLEC in contact with PbA lysate. In vivo, this treatment led to an improvement in the survival rate and in lung histology, with the absence of lung edema, higher alveolar area percentage, and the absence of pleural effusion at necropsy. Here, HMOX1 is linked to Pleural effusion.