CXCR1 and infectious disease: Functionally significant changes in CXCR1 and CXCR2 have been described in infectious diseases and human melanoma6, 7, but studies on the changes of CXCR1 and CXCR2 on neutrophils and the crosstalk between IL-8 and CXCR1/2 are still lacking in ACLF patients.