Whereas CUG2 overexpression activates Ras and MAPKs including p38 MAPK, which eventually facilitates oncolytic reoviral replication [4], CUG2 confers resistance to oncolytic vesicular stomatitis virus infection [5] and induces faster cell migration and anti-cancer drug resistance through activation of Stat1 [6]. This evidence concerns the gene CENPW and cancer.