In order to investigate whether MED15 up-regulation following ADT may be affected by PI3K activity, we investigated the correlation between them and observed that MED15 correlates significantly with PI3K activity in PCa tissues, and that PCa samples expressing high levels of pAKT harbored increased MED15 expression (Figure 2a, 2b, 3a). This evidence concerns the gene MED15 and posterior cortical atrophy.