In the present study, we selected eight potentially functional SNPs in four NER genes (e.g., XPC, XPD, XPF, and XPG) to examine their associations with risk of PCa in a relatively large hospital-based case-control study of 1,004 PCa patients and 1,055 cancer-free controls of an Eastern Chinese Han population. Here, ERCC5 is linked to posterior cortical atrophy.