The multivariate logistic regression analyses with a dominant genetic model indicated that XPC rs1870134 CG/CC was associated with an decreased risk of PCa, particularly in subgroups of age > 65 [adjusted OR = 0.78 (0.63-0.97), P = 0.023], body mass index (BMI) ≤ 24kg/m2 [adjusted OR = 0.70 (0.56-0.86), P = 0.0007], ever smokers [adjusted OR = 0.75 (0.60-0.94), P = 0.012], and Gleason score ≤ 7(3+4) [adjusted OR = 0.72 (0.56-0.93), P = 0.012], compared with the homozygous wild-type genotype. This evidence concerns the gene XPC and posterior cortical atrophy.