XPC and urinary bladder carcinoma: Although the findings for XPC rs2228001 were inconsistent among published studies, a recent large meta-analysis found that rs2228001 CC carriers may have an increased cancer risk of several cancer types, especially for cancers of the bladder, lung, colorectum, compared with GG/GC carriers, indicating that the effects of XPC SNPs on cancer risk are unlikely to be tissue-specific [34].