Amplifications of 3p26.33 (SOX2-OT), 8q24.21 (MYC), 14q21.1 (FOXA1) and deletion of 3p12.1 (GBE1) were found as the recurrent CNAs in metastasis group only, which indicated that those CNAs might be associated with metastasis in superficial ESCC. This evidence concerns the gene FOXA1 and esophageal squamous cell carcinoma.