Amplifications of 3p26.33 (SOX2-OT), 8q24.21 (MYC), 14q21.1 (FOXA1) and deletion of 3p12.1 (GBE1) were found as the recurrent CNAs in metastasis group only, which indicated that those CNAs might be associated with metastasis in superficial ESCC. The gene discussed is GBE1; the disease is esophageal squamous cell carcinoma.