CXCR4 and pachyonychia congenita: New to science, the results identified that a high-polarity extraction of seaweed polyphenol, HT-EA, not only mitigates therapy-associated onset of the TIM transcriptome in surviving PC cells and residual tumors, but also selectively targets radiation-induced CXCR4-/COX-2-dependent dissemination destiny of surviving PC cells.