For the analysis stratified by cancer type, significant association between KPNA2 overexpression and poor OS was observed in patients with gastric cancer (HR = 2.353, 95% CI = 1.048-5.284, P = 0.038) and colorectal cancer (HR = 3.252, 95% CI = 1.82-5.811, P<0.001), but not in patients with breast cancer (HR = 1.588, 95% CI = 0.996-2.531, P = 0.052). Here, KPNA2 is linked to gastric cancer.