TOP2A and acute myeloid leukemia: Drugs targeting DNA topoisomerase II (TOP2 poisons) are important, effective, and widely used anticancer agents, but they are associated with short- and long-term toxic side effects, including neutropenia and rare but life-threatening therapy-related acute myeloid leukemia (t-AML) (Allan and Travis, 2005; Leone et al., 2010; Cowell and Austin, 2012).