A second effect of COMBO treatment on myeloid compartment is an increase in a subpopulation expressing neuropilin‐1 and CD11b, which have been reported to favor vascular normalization and inhibit tumor growth when directly injected in B16.F10 melanomas at relative high cell concentration (2 × 105 cells/tumor) (Carrer et al, 2012). This evidence concerns the gene ITGAM and melanoma.