These results indicate that compensatory extramedullary hematopoiesis occurs in USP10-KO spleen, and complements the number of RBCs and Hb in USP10-KO mice (Figure 2A), but this compensatory system eventually breaks down, leading to severe anemia and early lethality in USP10-KO mice. Here, GSTM1 is linked to anemia (phenotype).