Like the repression of WNT-TCF responses, the repression of epigenetic regulators may have general components as it was also detected with cell type specific variations after 500nM treatment with CAP2 (batch 4) for 16h in CC14 and HT29 human colon cancer, MeWo human melanoma, U87 and U251 human glioma, and H358 lung cancer cells (Fig 5C). Here, HNF4A is linked to central nervous system cancer.