Here we have tested the modulation of selected WNT-TCF, cytokine and BMP signature markers, as well as the expression of the three most repressed genes by CAP2 encoding epigenetic regulators in human Ls174T colon cancer cells by withanolide A and withanolide B. None reproduced the signature changes of CAP2 (S11 Fig). The gene discussed is CAP2; the disease is malignant colon neoplasm.