TNFSF11 and prion disease: In contrast, RANKL-treatment significantly enhanced prion disease pathogenesis as seven of eight RANKL-treated mice exposed to a limiting dose of prions succumbed to clinical disease with significantly shorter survival times (Fig 8A; RANKL-treated mice, mean 352±22 d, median 350 d, n = 7/8; P<0.0078, Log-rank [Mantel-Cox] test).