Non-coding SNPs in LDLR have also been reported to be functional, for example, in the promoter region c.-139C>G [12], c.-101T>C, c.-121T>C [13], and -49C>T [14], and rs17248720 in the intergenic region [15] are involved in regulation of gene expression and have been reported to cause FH. Here, LDLR is linked to familial hyperaldosteronism.