In addition, in a recent study in cultured rat L6 muscle cells, cLDL decreased glucose uptake and glucose transporter 4 (GLUT4) to the membranes suggesting that cLDL may be involved in the development of type 2 diabetes and thus, it is possible that prevention of glucose uptake in endothelial cells may result in the induction of autophagy due to starvation. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.