Sandangeretal et al. reported that the NLRP3 inflammasome was predominantly upregulated in the left ventricle after myocardial infarction (MI) and primarily located in cardiac fibroblasts, which contributes not only to the myocardial fibrosis process, but also cardiac disease development due to the production of autocrine/paracrine factors [5]. The gene discussed is NLRP3; the disease is myocardial infarction.