AGO1 and benign prostatic hyperplasia: Xu et al. (2013) [109] comprehensively investigated the repertoire of core genes involved in siRNA and miRNA pathways in the BPH and the results demonstrated that the miRNA pathway was involved in BPH metamorphosis as depletion of the Argonaute (AGO1) or Dicer (Dcr-1) genes severely impaired ecdysis.