NFKB1 and obesity due to melanocortin 4 receptor deficiency: While the impact of diet and exercise on adiponectin is controversial, the anti-inflammatory activity of this adipokine, able to inhibit NF-κB and TNF-α production in macrophages, is well established (Figure 1); consistent with these data, its serum concentrations are inversely related to obesity and chronic metabolic disorders, such as insulin resistance and diabetes.