Currently there are two active clinical trials (Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NCT01913340) and Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy (NCT01732146)) examining EPO in combination with hypothermia in infants with HIE. This evidence concerns the gene EPO and perinatal asphyxia.