GLP1R and type 2 diabetes mellitus: Although it is not clear if an inhibition of L-cell secretion or an increase in GLP-1 degradation contribute to the lower incretin effect in type 2 diabetes, the intake of low-GI isomaltulose has been shown to increase GLP-1 secretion compared to sucrose in type 2 diabetes [41] and may therefore improve postprandial vasodilatation.