Zhou et al. [59] show that the ectopic expression of p53 GOF mutants (p53R175H and p53P151S) inhibits AMPK activity and subsequently reduces phosphorylation of ACC under glucose and serum starvation in a p53-null head and neck squamous cell carcinoma (HNSCC) cell line, UMSCC1. The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.