TP53 and cancer: Liu et al. [25] also generate mice having a cancer-associated mutation in the Mdm2 gene at codon 305 (Mdm2C305F) which disrupts the interaction of Mdm2 with ribosomal proteins (RPs), RPL11 and RPL5; during ribosomal stress, these RPs bind to Mdm2 and inhibit Mdm2’s function towards p53, hence activating p53 [46].