CCR5 plays a role in Treg cell migration to sites of P. brasiliensis infection in the lung, as loss of CCR5 results in impaired Treg accumulation and subsequently enhanced effector responses concomitant with improved granuloma formation and enhanced control of disseminated disease; adoptive transfer of Treg cells from infected wild type (WT) mice into the lungs of infected CCR5−/− mice leads to enhanced disease [60]. The gene discussed is CCR5; the disease is Granuloma.