IL10 and cryptococcosis: In addition to IL-10 production, moDCs also upregulate Programmed cell death protein ligands 1 and 2 (PD-L1 and PD-L2) in response to cryptococcal mannoprotein in vitro and in response to persistent cryptococcal infections in vivo (unpublished observations); further discussion of the IL-10 and PD-1 signaling pathways can be found later in this review.