Similarly, the percentages of PD-L1+MDSCs significantly increased as the stage of HCC advanced (healthy donor vs TNM I/II vs TNM III/IV; 0.079% vs 0.33% vs 0.87%) (healthy donor vs TNM I/II; p < 0.05, healthy donor vs TNM III/IV; p < 0.001, TNM I/II vs TNM III/IV; p < 0.01) (Fig. 1c). This evidence concerns the gene CD274 and hepatocellular carcinoma.