Ten human colorectal cancer cell lines and other types of cancer cell lines including HeLa (cervix), A549 (lung), PC3 (prostate) and U87-MG (brain) exhibited similar NQO1-mediated HIF-1α induction in both normoxia and hypoxia (Supplementary Fig. 4c,d). The gene discussed is NQO1; the disease is colorectal cancer.