Furthermore, we found the mutational status of the histone methyltransferase SET-domain containing-2 (SETD-2) as a significant contributor in kidney (Supplementary Fig. 11c), smoking in bladder and lung (Supplementary Fig. 11d,f), and isocitrate dehydrogenase 1 (IDH1) mutational status in brain cancers (Fig. 4g). Here, SETD2 is linked to brain cancer.