Furthermore, we found the mutational status of the histone methyltransferase SET-domain containing-2 (SETD-2) as a significant contributor in kidney (Supplementary Fig. 11c), smoking in bladder and lung (Supplementary Fig. 11d,f), and isocitrate dehydrogenase 1 (IDH1) mutational status in brain cancers (Fig. 4g). The gene discussed is IDH1; the disease is brain cancer.