Male mice of Loxl2-null and their littermate control (ActinCreERT; Loxl2fl/+ or Loxl2fl/fl, Loxl2fl/+) at 8–10 weeks of age were then subjected to TAC and followed for the development of HF for 10 weeks (Fig. 5a). The gene discussed is LOXL2; the disease is hydrops fetalis.