Similar to MTHFR 677, MTHFR 1298 CC and AC polymorphisms played protective roles against ALL and AML in European children, cases aggregated, in 4 studies (RR = 0.89, 95% CI [.82, .98], p = .0124), while the AA wildtype was associated with increased risk of ALL and AML, cases aggregated, in the same studies (RR =1.12, 95% CI [1.03, 1.23], p = .0126) (Table 1B, Supplementary Table S3). Here, MTHFR is linked to acute myeloid leukemia.