Importantly, innate immune stimuli (e.g. oncolytic virus (VSVΔ51-GFP), interferon γ (IFNγ), and tumour necrosis factor-like weak inducer of apoptosis (TWEAK)) synergize with LCL161 in vitro to promote TNFα signaling and reduce cell viability in Kym-1 RMS cancer cells. This evidence concerns the gene TNF and cancer.