As shown in Table 3, Figure 2 and Figure 3, the pooled results indicated that the correlation between FGFR2 rs2981582 polymorphism and the occurrence of BC was significant in any genetic model: Allele model (OR: 1.23; 95% CI: 1.19- 1.26; P< 0.00001), Dominant model (OR: 1.29; 95% CI: 1.24-1.34; P< 0.00001), Recessive model (OR: 1.35; 95% CI: 1.31-1.40; P<0.00001), Homozygous genetic model (OR: 1.50; 95% CI: 1.42-1.58; P< 0.00001), Heterozygote comparison (OR: 1.22; 95% CI: 1.17-1.27; P< 0.00001). This evidence concerns the gene FGFR2 and breast cancer.