CDH2 and cancer: Several epithelial markers such as (I) epithelial keratins included E-cadherin, occludins, claudins, and desmoplakin are down-regulated and (II) acquire mesenchymal traits included vimentin, N-cadherin, fibronectin, and α-smooth muscle actin are up-regluated while development of EMT in cancer cells, these results will increase metastatic ability [9].