Female BRCA1/2-mutation carriers have a cumulative lifetime risk of BC up to 60–80%, and an increased risk of ovarian cancer (OC) up to 20–60% for BRCA1 and 5–20% for BRCA2 (Antoniou et al. 2003; Chen and Parmigiani 2007). This evidence concerns the gene BRCA1 and ovarian cancer.