The link with DGKs is provided by the observation that: i) aPKC binds to and is activated by PA (Limatola et al., 1994) and ii) their localization at the invasive protrusions of cancer cells is promoted by DGKα-produced PA (Chianale et al., 2010; Rainero et al., 2014). This evidence concerns the gene DGKA and cancer.