DGKZ and malignant colon neoplasm: DGKζ is also highly expressed in colon cancer cell lines and its expression correlates with enhanced cell motility due to increased Rac1 and RhoA activation (Cai et al., 2014), suggesting that DGKζ is a key regulator of Rho GTPase activity and cell migration in fibroblasts and tumor cells (Figure 2B).