Preliminary studies failed to demonstrate significant involvements of ROS and IL-10 (data not shown), issues requiring further immunological and biochemical studies; (iii) lymphocytes express Cftr, suggesting that Cftr in T-cells could affect the functional outcome of MDSC-T-cell interactions in CF lung disease, though preliminary data from our group showed no significant impact of T-cellular Cftr on MDSC-T-cell studies (data not shown); (iv) we observed in our suppression assays that beyond CD4+ cells, also non-CD4+ cells in the fraction of lymphocytes were proliferating. Here, CD4 is linked to lung disorder.