For example, polo-like kinase 2 (PLK2), which promotes α-syn phosphorylation, is upregulated in the brains of patients with Alzheimer's and LB disease [11, 12], while activity of protein phosphatase 2A (PP2A), which is responsible for α-syn dephosphorylation, is decreased in cases of dementia with LB and α-syn triplication [13, 14]. The gene discussed is PLK2; the disease is dementia.