In addition, one of the following should be fulfilled: pulse deficit or claudication, blood pressure discrepancy > 10 mm Hg in any limb, hypertension with systolic or diastolic > 95th centile for height, and erythrocyte sedimentation rate (ESR) > 20 mm/h or elevated C-reactive protein (CRP). The gene discussed is CRP; the disease is Hypertension.