Dominant mutations in NLRP3 may lead to a spectrum of inflammatory diseases including familial cold autoinflammatory syndrome (FCAS, OMIM # 120100), Muckle-Wells Syndrome (MWS, OMIM # 191900), and chronic infantile neurological cutaneous and articular syndrome (CINCA, OMIM # 607115). This evidence concerns the gene NLRP3 and Muckle-Wells syndrome.