NLRP3 and arthritic joint disease: In a large dominant family of European descent in the report [12], a majority or all of the thirteen affected family members with the p.E313K mutation in NLRP3 had MWS-related inflammatory symptoms including chronic fatigue (100%), recurrent fever (31%), headache (54%), ocular symptoms such as conjunctivitis (85%) and uveitis (77%), oral ulcers (46%), pericarditis (23%), abdominal pain (31%), renal amyloidosis (77%), musculoskeletal symptoms such as arthralgias (85%), arthritis (69%), and myalgia (54%), and erythematous rash (54%).