IL13 and asthma: Periostin has been used as a biomarker to predict the response to TH2-target therapy with humanized monoclonal antibody to IL-13 (lebrikizumab) in uncontrolled asthma patients: patients with high level of serum periostin at baseline showed a greater improvement with lebrikizumab treatment, in comparison with patients with low level of serum periostin [6].