In the general population and in cohorts of children with asthma, eNO has been used as a marker of airway inflammation– and has been associated with several features of atopic asthma such as total serum IgE, peripheral blood eosinophilia, and the FEV1/FVC ratio in children with asthma [49, 50]. The gene discussed is IGHE; the disease is Increased total eosinophil count.